Anti-interleukin-13 antibody therapy for asthma: one step closer
نویسندگان
چکیده
منابع مشابه
Anti-interleukin-13 antibody therapy for asthma: one step closer.
C urrent guidelines for the treatment of asthma recommend inhaled corticosteroids for all patients with persistent asthma. Despite the increasing use of these drugs, asthma remains poorly controlled in a small subset of individuals who do not respond fully to existing therapies. The medical needs of these patients have prompted a search for new medications that inhibit specific molecular target...
متن کاملReslizumab and Eosinophilic Asthma: One Step Closer to Precision Medicine?
Human eosinophils represent approximately 1% of peripheral blood leukocytes. However, these cells have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophilic inflammation is present in a significant proportion of patients with severe asthma. Asthma is a chronic inflammatory disorder that affects more than 315 million people worldwide, with 10% having severe unc...
متن کاملPhotodynamic therapy: novel third-generation photosensitizers one step closer?
Photodynamic sensitizers are drugs activated by light of a specific wavelength and are used in the photodynamic therapy (PDT) of certain diseases. Second- and third-generation photosensitizers with improved PDT properties are now under investigation. In this issue of the British Journal of Pharmacology, Leung et al. have described the synthesis and investigation of a second-generation photosens...
متن کاملTherapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice.
In vivo models have demonstrated that interleukin-13 (IL-13) plays an important role in asthma; however, few studies have evaluated the effect of inhibition of IL-13 on established and persistent disease. In the present study, we have investigated the effect of a therapeutic dosing regimen with an anti-IL-13 monoclonal antibody (mAb) in a chronic mouse model of persistent asthma. BALB/c mice we...
متن کاملAnti-interleukin-5 therapy and severe asthma.
Asthma is a chronic inflammatory disorder of the airways that leads to acute symptoms, exacerbations and sometimes, for a small part of the asthmatic population, fatal or near-fatal exacerbations. This as yet significant minority of individuals present with severe asthma and have persisting daily symptoms, and exacerbations despite compliance with high doses of inhaled steroids and additional t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2013
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00124212